يستعمل دواء نافيلوكا 200مجم 14 كبسولnaviluca 200 mg 14 caps. antifungals.triazoles antifungals.triazoles

about fluconazole -a triazole derivative a board range antifungal. - -mechanism of action of fluconazole -fluconazole is fungicidal or fungistatic depending on the drug concentrations. i t inhibits the conversion of lanosterol to 14 demethyl lanosterol by inhibiting the cytochromep450 enzyme 14 alpha demethylase and impair ergosterol synthesis - -interactions for fluconazole -cimetidine: decreased efficacy of fluconazole. -cyclosporine: increase in serum cyclosporine plasma concentration. -hydrochlorothiazide: reduction in renal clearance of fluconazole. -phenytoin: efficacy of phenytoin enhanced. -rifampicin: efficacy of fluconazole decreased higher dosage required. -sulfonylureas: efficacy of tolbutamide glyburide and glipizide increased. -warfarin: potentiates the anticoagulant effect resulting in increase in prothrombin time. - -indications for fluconazole -1.oesophageal candidiasis -2.oropharyngeal candidiasis -3.vaginal candidiasis -4.systemic candidiasis -5.cryptoc