يستعمل دواء بالميبروف 125مجم 30 اقراصpulmiprove 125 mg 30 f.c. tabs. endothelian receptor antagonist endothelian receptor antagonist

pharmacology - -endothelian receptor antagonist that blocks endothelin receptors on endothelium and vascular smooth muscle (stimulation of these receptors is associated with vasoconstriction). bosentan blocks both eta and etb receptors with a slightly higher affinity for the a subtype. - -indications - -pulmonary arterial hypertension: treatment of pulmonary artery hypertension (pah) (who group i) in patients with who/nyha class ii iii or iv symptoms to improve exercise capacity and decrease the rate of clinical deterioration. note: according to treatment guidelines from the fifth world symposium on pulmonary hypertension (wsph) only a small number of pah patients with who-fc iv symptoms (ie severely ill patients) were included in clinical trials therefore most experts consider bosentan second-line therapy in these patients (wsph [gail� 2013]).