يستعمل دواء افارا 100 مجم 3 اقراصavara 100mg 3 f.c. tab. (n/a) immunosuppressive agent.antirheumatic antiviral agent.pyrimidine synthesis inhibitor immunosuppressive agent.antirheumatic antiviral agent.pyrimidine synthesis inhibitor

about leflunomide -a pyrimidine synthesis inhibitor isoxazole derivative disease-modifying antirheumatic drug. - -mechanism of action of leflunomide -this immunomodulatory drug inhibits dihydroorotate dehydrogenase (an enzyme involved in de novo pyrimidine synthesis) (abbreviation dhodh). it also has anti-inflammatory effect. this double action is slow progression of the disease and to cause remission/relief of symptoms of rheumatoid arthritis and psoriatic arthritis such as joint tenderness and decreased joint and general mobility in human patients. - -indications for leflunomide -1. rheumatoid arthritis -2. psoriatic arthritis -interactions for leflunomide -cholesturamine charcoal: co-administration with lefulnomide results in rapid and significant decrease in lefulnomide activity. -rifampicin: co-administration increases lefulnomide plasma levels. -hepatotoxic drugs: co-administration may increase side effects. -nsaids: increase in the free fraction of diclofenac and ibuprof