يستعمل دواء سينازين 25 مجم 50 قرصcinnazin 25mg 50 tab. antiemetic.promote cerebral blood flow.antihistamine calcium channel blocker antiemetic.promote cerebral blood flow.antihistamine calcium channel blocker

about cinnarizine -piperazines derivative antihistamine antivertigo. - -mechanism of action of cinnarizine -cinnarizine is a specific competitive h1 receptor antagonist. it suppresses the vestibular end organ receptors and thus inhibits the activation of central cholinergic receptors. cinnarizine inhibits contractions of vascular smooth muscles by inhibiting the calcium channels preferably in the arterial smooth muscle. - -indications for cinnarizine -1.motion sickness -2.vertigo and other vestibular disturbances -3.vomiting in meniere`s disease -4.treatment of vascular disorders (peripheral & cerebrovascular) - -typical dosage for cinnarizine -adult: -motion sickness: 30 mg to be taken 2 hour before beginning the journey and if necessary dose can be repeated every 8 hours -vertigo and other vestibular disturbances vomiting in meniere`s disease: 90 mg / day in 3 divided doses -treatment of vascular disorders (peripheral & cerebrovascular): 75 mg 1-3 times daily. -