يستعمل دواء كومبيفاسك 5/20 مجم 20 كبسولةcombivasc 5/20 mg 20 caps. anti-hypertensive.combined ace with calcium channel blocker anti-hypertensive.combined ace with calcium channel blocker

mechanism of action of amlodipine -amlodipine is a second generation dihydropyridine ca channel blocker. it exerts it`s antihypertensive antianginal actions through blocking the influx of ca ions through voltage gated l-type ca channels to the peripheral vascular smooth muscle cells coronary smooth muscle cells and to the myocardial cells. thus causes dilatation of vascular endothelium decrease peripheral resistance & reduce myocardial oxygen demand .it markedly relax arterioles and milder effects on veins. they do not compromise haemodynamics and cerebral and renal perfusion. -mechanism of action benazeprilat the active metabolite of benazepril competes with angiotensin i for binding at the angiotensin-converting enzyme blocking the conversion of angiotensin i to angiotensin ii. inhibition of ace results in decreased plasma angiotensin ii. as angiotensin ii is a vasoconstrictor and a negative-feedback mediator for renin activity lower concentrations result in a decrease in blo