يستعمل دواء كومادين 5 مجم 28 قرصcoumadin 5 mg 28 tablets (illegal import) anticoagulant.clotting factors activation inhibitors anticoagulant.clotting factors activation inhibitors

about warfarin -synthetic coumarin derivative vitamin k antagonist anticoagulant. -mechanism of action of warfarin -it exerts it`s pharmacological action by inhibiting regeneration of active hydroquinone from vitamin k and also behaves as a competitive antagonist of vitamin k. thus the drug interacts with synthesis of vitamin k derived clotting factors (factors; ii vii ix and x.) in a dose dependent manner and reduce their plasma levels. vitamin k-hydroquinone is required for final step of gama-carboxylation of descarboxy forms of these factors. this carboxylation is essential for the ability of the clotting factors to bind ca2+ and to get bound to phospholipid surfaces and ultimately involve in coagulation cascade. -indications for warfarin -1. thromboembolism -2. pulmonary embolism -3. transient ischemic attack -4. atrial fibrillation -5. rheumatic heart disease -6. deep vein thrombosis