يستعمل دواء ابيلات 10 مجم 30 كبسولةepilat 10mg 30 s.g.caps. antihypertensive.selective calcium channel blocker antihypertensive.selective calcium channel blocker

about nifedipine -a dihydropyridine calcium channel blocker antianginal antihypertensive tocolytic. -mechanism of action of nifedipine -nifedipine is a dihydropyridine ca channel blocker. it exerts it`s antianginal antihypertensive actions through blocking the influx of ca2+ ions through voltage gated l-type ca channels to the peripheral vascular smooth muscle cells coronary smooth muscle cells and to the myocardial cells. thus causes dilatation of vascular endothelium decrease peripheral resistance & reduce myocardial oxygen demand .it markedly relax arterioles and milder effects on veins decrease after load and increase cardiac index. it do not compromise haemodynamics and cerebral and renal perfusion. it inhibits platelet aggregation and relaxes bronchial uterine and ureteric smooth muscles. it is an effective uterine relaxant agent. -migraine: it is used in migraine by reducing intracellular ca+2 overload due to brain hypoxia and other causes.