يستعمل دواء ايبوسين 20 مجم / مل فيالeposin 20mg/ml vial antineoplastic antineoplastic

about etoposide -derivative of podophyllotoxin antineoplastic agent. - -mechanism of action of etoposide -this semi synthetic derivative of podophyllotoxin arrests cells in g2 phase. it stabilizes the dna cleavage normally catalysed by topoisomerase 2 and inhibits the relegation of dna.this drug also prevents the cells from entering mitosis and depressing rna&dna synthesis. - -interactions for etoposide -warfarin: prolongation of prothrombin time may occur. -other cytotoxic drugs: synergism. - -indications for etoposide -1. lung cancer -2. testicular cancer -3. lymphoma -4. non lymphocytic leukemia -5. glioblastoma multiforms -6. bladder cancer -7. brain tumor -8. germ cell tumor -9. gestational trophoblastic neoplasia -10. head and neck cancer -11. ovarian cancer -12. prostate cancer -13. ewings sarcoma -14. hepatoma -15. kaposi`s sarcoma -16. leukemia -17. neuroblastoma -18. rhabdomyosarcoma -19. wilm`s tumor