يستعمل دواء جرانيتريل 3 مجم/3 مل 6 امبولاتgranitryl 3mg/3ml 6 amps. i.v. 5-ht3 antagonist.anti-emetic 5-ht3 antagonist.anti-emetic

about granisetron -selective 5ht3 receptor antagonist tropane derivative antiemetic antinauseant. - -mechanism of action of granisetron -granisetron is a selective 5ht3 receptor antagonist. 5ht3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain. -cytotoxic chemotherapy is associated with release of serotonin from enterochromaffin cells in the small intestine. serotonin triggers vomiting through 5ht3 vagal receptor that activates the vomiting reflex. since granisetron is a 5ht3 receptor antagonist it is indicated for the prevention of nausea and vomiting associated in chemotherapy. - -indications for granisetron -1.nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy.