يستعمل دواء هايكمتين 4 مجم فيالhycamtin 4mg vial(n/a) antineoplastic antineoplastic

about topotecan -a topoisomerase i inhibitor natural source (plant) derivative antineoplastic. -mechanism of action of topotecan -this antineoplastic drug inhibits the action of enzyme topoisomerase 1(this enzyme produces reversible single strand breaks in dna during dna replication) by binding to it. this results topoisomeras1-dna complex and prevents the relegation of dna strand resulting in double strand dna breakage and cell death. the drug has also radiation-sensitizing ability. -indications for topotecan -1. ovarian cancer -2. lung cancer -3. chronic myelomonocytic leukemia (cmml) -4. myelodysplastic syndrome (mds) -5. glioma -6. multiple myeloma -7. neuroblastoma -8. pancreatic cancer -9. rhabdomyosarcoma -10. ewing`s sarcoma