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about paliperidone -antipsychotic -mechanism of action of paliperidone -paliperidone is a benzisoxazole atypical antipsychotic which is a main active metabolite of risperidone. it is reported to be an antagonist at dopamine d2 serotonin (5-ht2) adrenergic a1 and a2 receptors and histamine (h1) receptors. it is used for the acute and maintenance treatment of schizophrenia. -indications for paliperidone -1.schizophrenia -2.severe depression -3.anxiety -4.obsessive thoughts -interactions for paliperidone -1.increased risk of antipsychotic-related extrapyramidal symptoms when used with central acetylcholinesterase inhibitors. -2.may reduce the therapeutic effect of anti-parkinson`s agents (dopamine agonist). -3.serum levels may be reduced by carbamazepine. -4.concurrent use may increase toxicity of other cns depressants. -5.serum levels may be increased by itraconazole. -6.lithium may increase neurotoxic effects of paliperidone.