يستعمل دواء جاكراندا 0.5 مجم 4 أقراصjakaranda 0.5 mg 4 tabs. dopamine agonist and prolactin inhibitor dopamine agonist and prolactin inhibitor

description -cabergoline an ergot derivative is a long-acting dopamine agonist and prolactin inhibitor. it is used to treat hyperprolactinemic disorders and parkinsonian syndrome. cabergoline possesses potent agonist activity on dopamine d2 receptors. - -indication -for the treatment of hyperprolactinemic disorders either idiopathic or due to prolactinoma (prolactin-secreting adenomas). may also be used to manage symptoms of parkinsonian syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease. - -mechanism of action the dopamine d2 receptor is a 7-transmembrane g-protein coupled receptor associated with gi proteins. in lactotrophs stimulation of dopamine d2 causes inhibition of adenylyl cyclase which decreases intracellular camp concentrations and blocks ip3-dependent release of ca2+ from intracellular stores. decreases in intracellular calcium levels may also be brought about via inhibition of calcium