يستعمل دواء كوناكيون مم للأطفال 2 مجم / 0.2 مل 5 امبولkonakion mm paediatric 2mg/0.2ml 5 amp. i.m./i.v./oral vitamin k vitamin k

about vitamin k -fat soluble vitamin antihemorrhagic. -mechanism of action of vitamin k -phytonadione (vitamin k1) is a synthetic form of vitamin k and is lipid soluble. vitamin k acts as a cofactor in the synthesis of coagulation proteins; prothrombin factors vii ix and x by liver. vitamin k dependent changes in the final stage of synthesis of these coagulation proteins is gama-carboxylation of glutamate residues of these zymogen proteins and their descarboxy-forms converted in to active forms; which confers on them the capacity to bind ca2+ and to get bound to the phospholipid surfaces which are essential properties for participation in the coagulation cascade.