يستعمل دواء لاكوساميت 100 مجم 10 اقراصlacosamet 100 mg 10 f.c. tabs. anti-epileptic anti-epileptic

pharmacology - -precise mechanism of action is unknown; however lacosamide selectively enhances slow inactivation of voltage-gated sodium channels resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing. - -indications and usage -oral - -adjunctive treatment of partial-onset seizures. -parenteral - -adjunctive treatment of partial-onset seizures when oral route is not feasible. - -dosage and administration -partial-onset seizures -adults and children 17 y of age and older - -po/iv start with 50 mg twice daily. the dosage may be increased by 50 mg twice daily at weekly intervals up to the recommended maintenance dosage of 200 to 400 mg/day based on response and tolerability. -hepatic function impairment -adults and children 17 y of age and older - -po/iv titrate the dose with caution. max dosage of 300 mg/day is recommended in patients with mild or moderate hepatic impairment. not recommended in patients with severe hepatic impairm