يستعمل دواء ليتروزول 2.5 مجم 10 اقراصletrozole 2.5mg 10 f.c.tabs. non-steroidal aromatase inhibitor non-steroidal aromatase inhibitor

about letrozole -non-steroidal aromatase inhibitor antineoplastic. - -mechanism of action of letrozole -this aromatase enzyme inhibitor competitively and reversibly bind to the heme portion of cytochrome p450 unit of aromatase enzyme (which convert the androgens to estrogens) and inhibit its activity. -it causes the reduction in plasma estrogen level and then the growth of estrogen related tumors growth. - -indications for letrozole -1. breast cancer especially in post menopausal woman. -2. pre-operative treatment in post-menopausal women with localized hormone-receptor-positive breast cancer. -typical dosage for letrozole -oral- -adult- -2.5mg once daily. - -contra-indications of letrozole -1. hypersensitivity to the drug and its components -2. severe hepatic impairment -3. premenopausal woman