يستعمل دواء لوبرانست 2 مجم 20 قرصlopranest 2 mg 20 orodispersible films antidiarrhoeal antidiarrhoeal

about loperamide -a synthetic piperidine derivative opioid antidiarrhoeal analgesic. -mechanism of action of loperamide -loperamide is a mu receptor agonist. it inhibits the release of acetylcholine on myenteric plexus in the gastrointestinal tract. this results in slowing intestinal motility and reduces peristalsis and increase intestinal transit time. this will results in increased absorption of water from fecal matter. loperamide also has a direct action on intestinal smooth muscle. it does not have any effect on central nervous system. -indications for loperamide -1.diarrhoea -typical dosage for loperamide -adult (oral): initial dose: 4 mg followed by 2 mg after each loose motion. maintenance dose: 6 - 8 mg daily -maximum dose: 16 mg / day -children: -2 - 5 years: 3 mg / day in 3 divided doses -6 - 8 years: 4 mg / day in 2 divided doses -8 - 12 years: 6 mg / day in 3 divided doses