يستعمل دواء لوسارميفا - 50 مجم 14 قرصlosarmepha-50 mg 14 f.c. tabs. anti-hypertensive.angiotensin blocker anti-hypertensive.angiotensin blocker

about losartan potassium -an angiotensin ii receptor antagonist antihypertensive. - -mechanism of action of losartan potassium -it is a competitive antagonist of angiotensin-2 at at-1 receptor. it decreases peripheral resistance and lowers bp in hypertensive individuals. it blocks all overt actions of angiotensin-2 such as: - 1. vasoconstriction 2. central & peripheral sympathetic stimulus 3. release of aldosterone and adrenaline 4. salt and water reabsorption 5. central actions like thirst vasopressin release and growth promoting actions on heart and blood vessels. - -interactions for losartan potassium -diuretics other antihypertensives: potentiate the hypotensive effect of losartan. -potassium sparing diuretics potassium suppliments: risk of hyperkalaemia. -nsaids: may blunt hypotensive effect of losartan. -cytochrome p450 inhibitors like ketoconazole: increase in auc of losartan by 18 % but has no effect on its active metabolite. -