يستعمل دواء ميثوتريكسيت 2.5مجم 50 اقراصmethotrexate-ebewe 2.5mg 50 tab. antineoplastic antineoplastic

about methotrexate -antimetabolite antifolate immunosuppressant antineoplastic antirheumatic. -mechanism of action of methotrexate -drug inhibits the enzyme dihydrofolate reductase (dhfr) which catalyses the conversion of dihydrofolate to active tetrahydrofolate.it is an important step in the folic acid synthesis. folic acid is needed for the de novo nucleoside thymidine required for dna synthesis. drug therefore inhibit the synthesis of dna rna and protein. in lower doses it inhibit the enzyme involved in purine metabolism leading to accumulation of adenosine or the inhibition of t-cell activation and suppression of intercellular adhesion molecule expression by t-cells. -indications for methotrexate -1. acute lymphoblastic leukemia -2. choriocarcinoma -3. burkitt`s lymphoma -4. meningeal leukemia -5. lymphosarcoma -6. hydatidiform mole -7. psoriasis -8. rheumatoid arthritis -9. corticosteroid dependant asthma -10. non metastatic osteosarcoma -11. mycosis fungoides