يستعمل دواء متروهيلر 12مكجم 30 كبسول metrohaler 12 mcg 30 cap+inhaler bronchodilator.long acting beta 2 agonist bronchodilator.long acting beta 2 agonist

mechanism of action -the pharmacologic effects of beta2-adrenoceptor agonist drugs including formoterol are at least in part attributable to stimulation of intracellular adenyl cyclase the enzyme that catalyzes the conversion of adenosine triphosphate (atp) to cyclic-3 5 -adenosine monophosphate (cyclic amp). increased cyclic amp levels cause relaxation of bronchial smooth muscle and inhibits the release of pro-inflammatory mast-cell mediators such as histamine and leukotrienes. formoterol also inhibits histamine-induced plasma albumin extravasation in anesthetized guinea pigs and inhibits allergen-induced eosinophil influx in dogs with airway hyper-responsiveness. the relevance of these in vitro and animal findings to humans is unknown. - -