يستعمل دواء اوكسيتوسين 5وحدة/مل 10 امبولoxytocin 5 iu/ml 10 amp. smooth muscle constrictor smooth muscle constrictor

mechanism of action of oxytocin -oxytocin binds to g-protein coupled receptors. in human myometrium these receptors couple to gq and g11 receptors. this will activate phospholipase -c hydrolysis and generate inositol triphosphate (ip3) and diacyl glycerol. these will mobilizes calcium ion from calcium deposits and also enhances voltage sensitive ca2+ channels. this ca2+ produces contraction. oxytocin also increases local prostaglandin production and stimulates uterine contractions. -indications for oxytocin -1. induction of labour -2. augmentation of labour -3. reduction of postpartum bleeding -4. induce abortion -5. oxytocin challenge test -interactions for oxytocin -sympathomimetics: pressor effect of sympathomimetics may be increased leading to postpartum hypertension. -prostaglandins: risk of uterine repture & cervical lacerations. -ergotamine: synergistic effect in control of post partum haemorrhage.