يستعمل دواء بلينديل 5مجم 30 اقراصplendil 5mg 30 prolonged release f.c. tab. antihypertensive.selective calcium channel blocker antihypertensive.selective calcium channel blocker

about felodipine -a selective calcium channel blocker dihydropyridine derivative anti hypertensive. -mechanism of action of felodipine -felodipine is a vasoselective long acting dihydropyridine ca channel blocker. it exerts antihypertensive antianginal actions through blocking the influx of ca2+ ions through voltage gated l-type ca channels to the peripheral vascular smooth muscle cells coronary smooth muscle cells and to the myocardial cells. thus causes dilatation of vascular endothelium decrease peripheral resistance & reduce myocardial oxygen demand .it has smooth muscle relaxant action produces by release of nitric oxide from endothelium and thus inhibit cyclic amp-phosphodiesterase resulting in raised cyclic amp in smooth muscle. nitric oxide exerts anti atherosclerotic action.