يستعمل دواء ريباجليد 0.5مجم 20 اقراصrepaglid 0.5mg 20 tab. anti-diabetic.secretagogues.glinides anti-diabetic.secretagogues.glinides

about repaglinide -meglitinide derivative insulin secretagogue oral anti-diabetic drug. -mechanism of action of repaglinide -it is a quick and short acting antidiabetic drug which exerts it`s action by stimulating insulin release from -cells of pancreas. it acts by binding to sulfonylurea receptor and to other distinct receptors and closes atp dependent potassium channels and thus causes depolarization. this depolarization of pancreatic cells causes opening of ca channels and increased ca influx which induces insulin secretion. -indications for repaglinide -non-insulin dependent diabetes mellitus (as adjunct to diet and exercise) -interactions for repaglinide -ketoconazole miconazole and erythromycin: metabolism of repaglinide inhibited. -troglitazone rifampicin barbiturates and carbamazepine: increase metabolism of repaglinide.