يستعمل دواء رومافين فورت لبوسrheumafen forte supp. nsaid.analgesic.combination nsaid.analgesic.combination

about diflunisal -nsaid salicylic acid derivative nonopioid analgesic anti-inflammatory. -diclofenac sodium -mechanism of action of diclofenac sodium -diclofenac possess analgesic anti-inflammatory and antipyretic action. it inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of prostaglandins (pgs). it is more potent against cyclo-oxygenase-2 enzyme as compared to other nsaids like indomethacin naproxen etc. it reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. . -interactions for diclofenac sodium -lithium & digoxin : blood levels of lithium and digoxin increased leading to enhanced efficacy and posible toxicity. -diuretics : inhibits diuretics but efficacy of potassium sparing diuretics enhanced. -methotrexate : toxicity enhanced. -salicylates : efficacy of salicylates reduced. -cyclosporine : increases nephrotoxicity of both agents. -hydantoins : increases serum levels resulting in toxicity.