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يستعمل دواء فيلكاد 1مجم للاطفال فيالvelcade 1 mg pd. in vial for i.v. inj.(hospitals) antineoplastic antineoplastic
mechanism of action bortezomib is a reversible inhibitor of the chymotrypsin-like activity of the 26s proteasome in mammalian cells. the 26s proteasome is a large protein complex that degrades ubiquitinated proteins. the active site of the proteasome has chymotrypsin-like trypsin-like and postglutamyl peptide hydrolysis activity. the 26s proteasome degrades various proteins critical to cancer cell survival such as cyclins tumor suppressors bcl-2 and cyclin-dependent kinase inhibitors. inhibition of these degradations sensitizes cells to apoptosis. bortezomib is a potent inhibitor of 26s proteasome which sensitizes activity in dividing multiple myeloma and leukemic cells thus inducing apoptosis. in addition bortezomib appears to increase the sensitivity of cancer cells to traditional anticancer agents (e.g. gemcitabine cisplatin paclitaxel irinotecan and radiation).
تركيبة دواءفيلكاد 1مجم للاطفال فيالvelcade 1 mg pd. in vial for i.v. inj.(hospitals)
يتركب هذا الدواء من :bortezomib
الشركة المنتجة لدواءفيلكاد 1مجم للاطفال فيالvelcade 1 mg pd. in vial for i.v. inj.(hospitals)
هذا الدواء من انتاج شركة janssen cilag > soficopharm
جرعة دواءفيلكاد 1مجم للاطفال فيال
Welcome to Dlildwa, specifically the page of velcade 1 mg pd. in vial for i.v. inj.(hospitals).
تم استعراض بدائل هذا الدواء 257 مرة