يستعمل دواء زوفران 8مجم 10 اقراصzofran 8mg 10 tab. antiemetic antiemetic

about ondansetron -selective serotonin 5-ht3 receptor antagonist imidazole derivative antiemetic. -mechanism of action of ondansetron -ondansetron is a selective 5ht3 receptor antagonist. 5ht3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain. -cytotoxic chemotherapy is associated with release of serotonin from enterochromaffin cells in the small intestine. serotonin triggers vomiting through 5ht3 vagal receptor that activates the vomiting reflex. since ondansetron is a 5ht3 receptor antagonist it is indicated for the prevention of nausea and vomiting associated in chemotherapy. -anaesthetic adjuncts: it is used preoperatively in order to reduce the post operative vomiting.