يستعمل دواء كاليكس كونسنتريت 20مجم/10مل فيالcaelyx concentrate 20mg/10ml vial antineoplastic antineoplastic

about doxorubicin -anthracycline antibiotic antineoplastic agent. - -mechanism of action of doxorubicin -this anthracycline antibiotic intercalates the dna which directly affects the transcription and replication of dna. it forms a tripartite complex with topoisomerase 2 and dna.topomerase2 is an enzyme which is essential for the dna replication and repair. by these two mechanisms this drug can inhibit the growth of cancer cells. - -interactions for doxorubicin -mercaptopurine: hepatotoxicity of mercaptopurine enhanced leading to cholestasis. -cyclophosphamide: exacerbation of cyclophosphamide induced hemorrhagic cystitis. -barbiturates: increase the plasma clearance of doxorubicin. -digoxin: decreased serum levels of digoxin. -streptozotocin: increases toxicity of doxorubicin. -radiation: radiation induced toxicity to myocardium mucosa skin and liver increased.