يستعمل دواء سيمبالتا 60 مجم 28 كبسولةcymbalta 60 mg 28 caps. psychiatric.antidepressants psychiatric.antidepressants

about duloxetine -a serotonin-norepinephrine reuptake inhibitor thiophene derivative antidepressant. - -mechanism of action of duloxetine -duloxetine preferentially inhibits the re-uptake of noradrenaline and serotonin (5 ht) in the cns nerve terminals .this will result in an increased concentration of neurotransmitter serotonin in the synaptic cleft and produces antidepressant effect - -indications for duloxetine -1. major depressive disorder -2. diabetic peripheral neuropathic pain -3. generalised anxiety disorder - -typical dosage for duloxetine -major depressive disorder: 20 - 60mg / day in 2 divided doses -diabetic peripheral neuropathic pain:60 mg/day -generalized anxiety disorder: 60 mg/ day