يستعمل دواء ديرماتوب 0.25٪ كريم 10 جمdermatop 0.25% cream 10 gm glucocorticoid glucocorticoid

about prednicarbate -topical synthetic glucocorticoid anti-inflammatory. -mechanism of action of prednicarbate -prednicarbate is a topical synthetic glucocorticoid. -the drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. this structural change allows it`s migration in to the nucleus and then binding to specific sites on the dna which leads to transcription of specific m-rna and which ultimately regulates protein synthesis. it exerts highly selective glucocorticoid action. it stimulates the enzymes needed to decrease the inflammatory response. -the drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) induce lipocortins in macrophages endothelium and fibroblasts which inhibits phospholipase a2 and thus decreases the production of prostaglandins leukotrienes (lt) and platelet activating factor 2)