يستعمل دواء ديكلونيرف 30 كبسولةdiclonerve 30 caps. nsaid combined with vitamin b nsaid combined with vitamin b

mechanism of action of diclofenac sodium -diclofenac possess analgesic anti-inflammatory and antipyretic action. it inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of prostaglandins (pgs). it is more potent against cyclo-oxygenase-2 enzyme as compared to other nsaids like indomethacin naproxen etc. it reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. . -pharmacokinets of diclofenac sodium -absorption: diclofenac sodium is rapidly absorbed after oral administration. it undergoes first pass metabolism and its bioavailability is 50 % only. distribution: it is distributed in highly protein bound form. metabolism: diclofenac sodium is metabolised in the liver. excretion: drug and metabolites are primarily excreted in urine and some amount in the bile.