يستعمل دواء اريثروبريم 20 قرصerythroprim 20 f.c. tab. macrolide antibiotic macrolide antibiotic

about erythromycin -macrolide antibiotic. -mechanism of action of erythromycin -erythromycin is a member of macrolide antibiotics. it binds to the 50s sub unit of bacterial ribosome and inhibits translocation.ie: they interfere with the transfer of the newly formed peptide chain from the a site to the p site and fails to expose the a site .so that a site is unable to bind with the next aminoacyl t rna complex. this leads to premature termination of amino acid chain and there by inhibits protein synthesis. -interactions for erythromycin -anticoagulants: efficacy enhanced leading to haemorrhages. -bromocriptine: efficacy protentiated leading to toxicity. -carbamazepine: dangerous toxic side effects requiring resuscitative measures and hospitalisation. -digoxin: serum levels of digoxin enhanced leading to toxicity. -disopyramide: increased disopyramide plasma levels leading to arrhythmias. -ergot alkaloids: acute ergotism manifested as peripheral ischaemia. -