يستعمل دواء فيلوبريس 5/5 مجم 21 قرصfelopress 5/5 mg 21 f.c. tab. anti hypertensive anti hypertensive

about felodipine -a selective calcium channel blocker dihydropyridine derivative anti hypertensive. -mechanism of action of felodipine -felodipine is a vasoselective long acting dihydropyridine ca channel blocker. it exerts antihypertensive antianginal actions through blocking the influx of ca2+ ions through voltage gated l-type ca channels to the peripheral vascular smooth muscle cells coronary smooth muscle cells and to the myocardial cells. thus causes dilatation of vascular endothelium decrease peripheral resistance & reduce myocardial oxygen demand .it has smooth muscle relaxant action produces by release of nitric oxide from endothelium and thus inhibit cyclic amp-phosphodiesterase resulting in raised cyclic amp in smooth muscle. nitric oxide exerts anti atherosclerotic action.