يستعمل دواء هوبديتوكس 0.2 مجم 20 قرصhopdetox 0.2 mg 20 f.c. tab. addiction treatment addiction treatment

indication:investigated for use/treatment in addictions and substance abuse. -pharmacodynamics: lofexidine is an orally active imidazoline adrenergic alpha-2-receptor agonist; and is believed to have a high affinity for 2a receptor subtypes resulting in less anti-hypertensive activity than clonidine a non-selective alpha-2-receptor agonist. hypotension may occur in susceptible subjects accompanied by a decrease in heart rate. abrupt discontinuation of lofexidine has been in some cases associated with a transient increase in blood pressure to higher than pre-treatment levels. it selectively stimulates receptors in the brain that monitor catecholamine levels in the blood. these receptors close a negative feedback loop that begins with descending sympathetic nerves from the brain that control the production of catecholamines (epinephrine also known as adrenaline and norepinephrine) in the adrenal medulla.