يستعمل دواء لوفاستميد 40مجم 30قرصlovastmed 40mg 30 tabs antihyperlipidemic.statins antihyperlipidemic.statins

about lovastatin -statin class hmg-coa reductase inhibitor hypolipidemic agent. -mechanism of action of lovastatin -it is a precursor lactone hydrolyzed in to active beta-hydroxy acid which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme a (hmg coa) to mevalonate. the drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme a reductase (hmg coa reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. this results in compensatory increase in low density lipoprotein (ldl) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(idl) and low density lipoprotein (ldl). it causes dose dependent lowering of ldl cholesterol and reduces hepatic synthesis of very low density lipoprotein (vldl) and lowers plasma triglyceride levels. it also increases high density lipoprotein (hdl) levels.