يستعمل دواء ماجيسريليد 0.5مجم 10كبسولmagicrelide 0.5 mg 10 caps. thrombocythemia thrombocythemia

indication: -for the treatment of patients with thrombocythemia secondary to myeloproliferative disorders to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events. - -dosage: -adult- the recommended starting dose is 0.5 mg qid or 1 mg bid (2 capsules of 0.5 mg twice a day) and can be increased to 4 times daily. - -mechanism of action : -the mechanism by which anagrelide reduces blood platelet count is still under investigation. studies in patients support a hypothesis of dose-related reduction in platelet production resulting from a decrease in megakaryocyte hypermaturation. in blood withdrawn from normal volunteers treated with anagrelide a disruption was found in the postmitotic phase of megakaryocyte development and a reduction in megakaryocyte size and ploidy.